Heterogeneity of response to lipid-lowering therapy.

the follow-up (from 3 to 2 and 0), simply after evaluating them, performing the tilt table test and explaining the pathogenesis of the disease. This fact may explain Dr. Sra’s (2) skepticism on the medical capacity to prove the benefit of any treatment for vasovagal syncope. This could also be the reason why almost any treatment that has been tested for the therapy of vasovagal syncope has been considered to be effective (3). But we do not know whether a clinical diagnosis, reassuring the patient and explaining to the patient the postural maneuvers can be enough to provide symptomatic relief in most patients. We would like to congratulate Sheldon et al. for his efforts in establishing the role of beta-blockers for the treatment of vasovagal syncope. We share his frustrations in the treatment of this disabling and frequent disease. There is no doubt that new randomized and controlled studies are needed to reach a definitive answer. We are happy to have raised doubts on the efficacy of the drugs most commonly used for this pathology.